You want bad look at Enlarge Person. +2 Str, -2 Dex, and become Large. The benefits are +1 damage, 10 ft reach, and +4 on a few special attacks (grapple, trip, etc...). The negatives are -2 AC (-1 Dex, -1 size), -1 Reflex, -1 Initiative. Your to hit doesn't change (-1 size, +1 str). While there are cases where it would be worth it, for the most part I say hell no.
D&D 3E/3.5 - 3.5 Reduce Person--what's the point?
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